Aromatase Inhibitor (AI) Side Effects

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What are Aromatase Inhibitors?

Aromatase inhibitors are mainly used to treat hormone receptor-positive breast cancer. They work by blocking the enzyme aromatase, which turns the hormone androgen into estrogen in the body. Aromatase inhibitors do not work on hormone receptor-negative breast cancer.

Board-Certified Surgeon

MICHELE LEY, MD, FACS

Dr. Ley, a breast surgical oncologist in Tucson since 2006, delivers compassionate and personalized care to create tailored treatment plans based on the latest research. Specializing in surgical care for breast cancer and high-risk patients, she employs minimally invasive techniques and practices oncoplastic surgery to optimize outcomes.

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Because aromatase inhibitors cannot stop the ovaries from producing estrogen, these medications are mainly used to treat women who are post-menopausal.

There are 3 different types of aromatase inhibitors used to treat breast cancer, including anastrozole, exemestane, and letrozole. 

To learn more about aromatase inhibitors and their side effects, click the links below:

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Aromatase Inhibitor Side Effects

The most common side effects of aromatase inhibitors include:

  • Joint pain or stiffness
  • Decreasing bone density
  • Vaginal dryness
  • Hot flashes
  • Night sweats
  • Insomnia
  • Hair thinning

Aromatase Inhibitor Side Effect FAQs

Which aromatase inhibitor has the least side effects?

All aromatase inhibitors have side effects but not all patients experience them. Some experience no effects at all. Patients may experience side effects on one brand of AI but not on another. We sometimes switch to another brand to see if side effects are less.

Are there long-term side effects of taking aromatase inhibitors?

The only long term side effect can be osteopenia or osteoporosis. Patients on AI are monitored closely for this side effect and there are options for reducing the risk of worsening bone density.

Can aromatase inhibitors cause weight gain?

Some patients may experience weight gain, although is is usually less than 10 lbs if it occurs. Choosing to exercise while on AI, as well as following a plant-based diet can help minimize weight gain.

Can aromatase inhibitors interact with other medications?

They do not interact with other medications.

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If you have any questions or concerns regarding aromatase inhibitors, please do not hesitate to reach out to Tucson Breast Health Specialists in Tucson, AZ today. We are dedicated to helping you through each step of your breast health journey.

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