Reducing Chemotherapy and Mastectomy Complications

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Radiation can cause fibrosis (scarring) and reduce elasticity or stretchiness of the skin, and reduce blood supply to the tissues. Because of this, side effects may occur. Common side effects of radiation after mastectomy with implant reconstruction include capsular contracture, thinning of skin, tightening of skin, reduced range of motion and poor wound healing. However, there are some treatment methods to help reduce uncomfortable side effects, including the following.

Board-Certified Surgeon

MICHELE LEY, MD, FACS

Dr. Ley, a breast surgical oncologist in Tucson since 2006, delivers compassionate and personalized care to create tailored treatment plans based on the latest research. Specializing in surgical care for breast cancer and high-risk patients, she employs minimally invasive techniques and practices oncoplastic surgery to optimize outcomes.

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Pentoxifylline with Vitamin E

A combination of Pentoxifylline with Vitamin E is an effective option for the prevention and/or treatment of side effects of therapeutic radiation.

The regimen is to start right after the last radiation treatment is completed and is to be continued for 6-12 months.

Treatment regimen:

  • Pentoxifylline (Trental) 400 mg daily- on days 1-7
  • Pentoxifylline (Trental) 400 mg twice daily- on days 8-14
  • Pentoxifylline (Trental) 400 mg three times daily starting on day 15 and continued for 6-12 months
  • Vitamin E 400 IU once daily to continue from day 1

“The level of care is excellent.”

Dr. Ley is an excellent doctor who cares about her patients. She takes the time to explain everything and provides all options. The level of care is excellent.

Dr. Ley helped me through the first round of BC in 2017 with kindness, compassion and expertise! I had absolutely no reservations when trusting her for a 2021 and now for the 3rd time I can’t imagine going through this without her. She is a lion when it comes to fighting for you, calls you personally even though she has to be the busiest Dr. and mother I know. She’s considerate of your needs, fears and concerns and never lets you go it alone. Can’t say enough good!

Pentoxifylline is to be taken with a glass of water and always on a full stomach (after a meal).

Please make sure that we have a current list of your medications, and that it has been reviewed by your doctor before you start this regimen. Tell your surgeon you are taking these medications before procedures. Both medications may increase the risk of bleeding in some specific situations. 

Singulair

The medication Singulair (montelukast) is most known for treating allergies and asthma. However, it can be used to reduce the risk of capsular contracture and fibrosis after mastectomy, reconstruction, and radiation. It is taken once a day and is prescribed by your breast or plastic surgeon.

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For more information regarding treatments and methods for reducing treatment-related complications, please contact us today. At Tucson Breast Health Specialists in Tucson, AZ we are dedicated to educating our patients throughout their breast health journey.

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