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BRCA 1 & 2 Treatment
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At Tucson Breast Health Specialists, we provide expert care for patients with known genetic mutations, including the BRCA gene mutations. Led by Dr. Ley, our practice is dedicated to supporting individuals who have a suspected or confirmed genetic predisposition to breast cancer. If you are seeking treatment for a genetic mutation in Tucson, AZ, we offer personalized, state-of-the-art care tailored to your needs. 

Understanding BRCA and Genetic Mutations 

BRCA 1 and BRCA 2 tumor suppressor genes, meaning that they help to prevent cancer by repairing DNA damage and regulating cell growth. When these genes mutate, they may lead to an increased risk of developing breast cancer, ovarian cancer, and pancreatic cancer, and others. There are a number of other genetic mutations which can cause breast or other cancers, such as CHEK2, PALB2, TP53, and CDH1. For more information on genetic mutations, visit the Facing Our Risk website.

How is BRCA Mutation Diagnosed? 

Genetic testing is the most effective way to determine whether you carry a BRCA mutation. If you have a family history of breast or ovarian cancer or if your healthcare provider suspects a genetic predisposition, you may be recommended for a genetic counseling and testing session. These tests are performed through a simple blood or saliva sample and analyzed for specific mutations. 

How We Help Patients with a Breast Cancer Risk

At Tucson Breast Health Specialists, we help patients understand their breast cancer risk and ovarian cancer risk and create personalized care plans based on factors like personal and family history and genetic findings. Mutations in the BRCA1 and BRCA2 genes, often due to an inherited mutation, can raise the risk of breast cancer, ovarian cancer, and even pancreatic cancer. These breast cancer gene mutations are linked to hereditary breast cancers and increase the chances of developing ovarian cancer or a contralateral breast cancer.

Breast Cancer Screening and Breast Cancer Treatment

Through advanced breast and ovarian cancer screening, risk-reduction strategies, and cancer management, we support patients in efforts to prevent breast cancer, reduce breast cancer risk, and address primary breast cancer with confidence. We consider all relevant risk factors, discuss each patient’s lifetime risk, and offer access to leading breast cancer research, ensuring the highest level of care for our breast cancer patients. We guide patients from diagnosis to treatment of cancer cells with expert support.

Who Should Consider Genetic Testing? 

Genetic testing and counseling may be beneficial for individuals with a higher risk of inherited cancer gene mutations, particularly those with a personal cancer history or who have family members with a cancer history. Women diagnosed with breast cancer, especially at a young age, with triple-negative breast cancer, a second breast cancer diagnosis, or a family history of breast, ovarian, pancreatic, or prostate cancer, may benefit from testing. Additionally, individuals without cancer but with a family history of BRCA or other mutations, male breast cancer, or multiple relatives affected by breast or other related cancers, such as ovarian, pancreatic, prostate, melanoma, or rare cancers, should also consider genetic counseling to assess their risk. At Tucson Breast Health Specialists, we offer genetic counseling.  

Treatment Options for BRCA-Positive Patients 

For patients who test positive for BRCA mutations, our clinic offers comprehensive treatment and risk-reduction strategies: 

  • Enhanced Surveillance: Frequent breast imaging, including mammograms, MRIs, and ultrasounds, to detect cancer at its earliest stage. 
  • Risk-Reducing Surgery: Prophylactic mastectomy or oophorectomy may be recommended for individuals at high risk. 
  • Medications for Risk Reduction: Certain medications, such as Tamoxifen and Raloxifene, can help lower the risk of developing breast cancer. 
  • Advanced Breast Cancer Treatment: If cancer is diagnosed, we provide access to surgical, medical, and radiation therapy options tailored to BRCA-positive patients. 

Why Choose Tucson Breast Health Specialists? 

At Tucson Breast Health Specialists, we prioritize personalized, patient-centered care. Dr. Ley focuses on advanced diagnostic techniques and cutting-edge treatment plans designed specifically for individuals with BRCA mutations. We work closely with oncologists, genetic counselors, and surgeons to ensure a multidisciplinary approach to your breast health. 

Schedule a Consultation 

If you have a known BRCA mutation or another mutation and need expert guidance on your next steps, Tucson Breast Health Specialists is here to help. Contact us today to schedule an appointment with Dr. Ley and learn more about your options for BRCA treatment in Tucson, AZ. 

BRCA Frequently Asked Questions

How do BRCA mutations affect breast cancer risk?

Mutations in the BRCA1 or BRCA2 genes significantly increase the risk of developing breast cancer, often at a younger age than the general population. These mutations can also raise the risk of other cancers, including ovarian cancer.

Who should get genetic testing for BRCA mutations?

Genetic testing is recommended for individuals with a strong family history of breast, ovarian, pancreatic, or prostate cancer, or who have relatives known to carry BRCA mutations. Your doctor or genetic counselor can help determine if testing is appropriate for you.

How is BRCA testing performed?

BRCA testing is done through a simple blood test or saliva sample. The sample is analyzed in a laboratory to look for changes in the BRCA1 and BRCA2 genes. Most genetic testing also looks for other common genes associated with higher risk for breast cancer.

At what age should BRCA testing be done?

Testing is often recommended for adults aged 25 and older who may be at increased risk. In some high-risk families, testing may be discussed earlier.

What preventative measures should BRCA carriers take?

BRCA carriers may choose increased screening, preventive medications, or risk-reducing surgeries such as mastectomy or removal of the ovaries and fallopian tubes. The right plan depends on individual risk factors and should be discussed with a breast cancer surgeon and high risk gynecologist.

Is BRCA testing covered by insurance?

Many insurance plans cover BRCA testing for individuals who meet certain risk criteria, especially when recommended by a physician. Coverage depends on your policy and should be verified with your insurance provider.

Can BRCA mutations be passed to children?

Yes. BRCA mutations are inherited in an autosomal dominant pattern, meaning there is a 50 percent chance of passing the mutation to each child, regardless of gender.

How common are BRCA mutations?

BRCA mutations are relatively rare in the general population, occurring in about 1 in 400 people. However, the rate is higher in certain groups, such as individuals of Ashkenazi Jewish descent.

What is the difference between BRCA1 and BRCA2?

Both BRCA1 and BRCA2 mutations increase the risk of breast and ovarian cancers, but they differ slightly in the cancers they are most strongly linked to and the average age of onset. BRCA1 is more often linked to triple-negative breast cancer, while BRCA2, in addition to increasing the risk of female breast cancer and ovarian cancer, BRCA2 has a stronger link to pancreatic cancer, male breast cancer and prostate cancer.

Should I still get BRCA testing if I am healthy?

Yes, if you meet the criteria for testing, knowing your BRCA status can help you take proactive steps to lower your risk or detect cancer early. Even healthy individuals can benefit from the information for future planning.

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Board-Certified Surgeon

MICHELE LEY, MD, FACS

Dr. Ley, a breast surgical oncologist in Tucson since 2006, delivers compassionate and personalized care to create tailored treatment plans based on the latest research. Specializing in surgical care for breast cancer and high-risk patients, she employs minimally invasive techniques and practices oncoplastic surgery to optimize outcomes.

More About Dr. Ley

“The level of care is excellent.”

Dr. Ley is extremely good at explaining your breast cancer, treatment options, and everything she is going to do. She is a masterful surgeon and uses plastic techniques to close incisions, leaving minimal scarring. In addition, she is warm, pleasant, and a lovely person. I am so happy that I found her based on a friend’s recommendation. I can’t say enough about her and the practice’s excellent care.

When diagnosed with Breast Cancer my daughter, which is a surgical nurse, started searching for a breast surgeon for me. Within a short period of time, she called stating “Mom, Dr Ley is the surgeon for you”! I have not been disappointed & have had nothing but positive experiences with Dr. Ley & her staff. They truly care.

I have no words to express my gratitude for Dr. Ley! I was diagnosed Feb. 2020 and Dr. Ley besides being the best in her field and doing an amazing job on my double mastectomy she was even able to save my nipples. She is also a remarkable human being, patient, kind very clear in explaining everything and making you feel heard and safe in her hands. I 100% recommend her and her very helpful, kind and amazing team! If you have recently been diagnosed this is the team you want to have your back!

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We are dedicated to providing the support you need. Contact us today to learn more about how we can help on your breast health journey.

We are only accepting patients with surgical breast diseases. We do not see patients for breast pain or without imaging in the last three months. If you have been diagnosed with one of the following, please submit the contact form or call our office at (520) 605-2778 to schedule your appointment.

  • Breast cancer, DCIS (ductal carcinoma in situ), LCIS (lobular carcinoma in situ), invasive ductal carcinoma, invasive lobular carcinoma, and any other breast malignancies such as sarcoma, and malignant phyllodes
  • Patients with known genetic mutations such as BRCA 1, 2, and others
  • Fibroadenoma, phyllodes tumor, radial scar, complex sclerosing lesion, papilloma >8mm, atypical papilloma, nipple mass or ulceration,
  • Granulomatous mastitis
  • Atypical ductal or lobular hyperplasia ( ALH, ADH), and any benign lesion with atypia