What Is Triple-Negative Breast Cancer?
in Tucson, AZ

Triple-negative breast cancer (TNBC) is a type of breast cancer with the absence of three common receptors found on many breast cancer cells. These are estrogen receptors, progesterone receptors, and the HER2 protein. Because these receptors are absent, hormone therapies and HER2-targeted treatments are ineffective for TNBC.

Breast cancer begins when abnormal cells grow uncontrollably in the breast tissue. The breast is made up of lobules, ducts, fatty tissue, and connective tissue. Triple-negative breast cancer often develops in the ducts and is considered an invasive form of breast cancer, meaning it can spread into surrounding breast tissue if not treated.

Although TNBC is less common than other breast cancer subtypes, effective treatment options are available at Tucson Breast Health Specialists, especially when diagnosed early.

Risk Factors for Triple-Negative Breast Cancer

Anyone can develop triple-negative breast cancer, but certain factors are associated with a higher likelihood of diagnosis. TNBC is more commonly seen in younger patients and in those with inherited genetic mutations, particularly BRCA1/2. It is also diagnosed at higher rates in some ethnic populations.

Having risk factors does not mean you will develop TNBC, and many patients diagnosed with this condition have no known risk factors. Regular breast screening and prompt evaluation of breast changes are essential for early detection.

How Is Triple-Negative Breast Cancer Diagnosed?

Diagnosis usually begins with breast imaging, such as a mammogram, ultrasound, or breast MRI, followed by a biopsy. During the biopsy, a small sample of tissue is examined to confirm cancer and determine receptor status. If triple-negative breast cancer is diagnosed, additional testing may be performed to assess lymph nodes or the body to determine whether the cancer has spread. This staging process helps guide treatment recommendations and surgical planning.

Triple-Negative Breast Cancer Treatment Options

Lumpectomy

A lumpectomy formally called partial mastectomy removes the tumor along with a small margin of surrounding healthy tissue while preserving most of the breast. This option is usually followed by radiation therapy.

Mastectomy

A mastectomy involves the removal of the entire breast and may be recommended for larger tumors, multiple areas of cancer, or based on genetic risk factors or patient preference.

Oncoplastic Breast Surgery

Oncoplastic breast surgery combines cancer removal with reconstructive techniques to help maintain or improve breast shape after surgery.

Lymph Node Surgery

Lymph node surgery helps determine whether cancer has spread beyond the breast. This may include a sentinel lymph node biopsy or the removal of additional lymph nodes, as indicated.

Chemotherapy

Many patients with triple-negative breast cancer also receive chemotherapy, either before surgery (neoadjuvant) or after surgery (adjuvant), as part of their comprehensive treatment plan.

Contact Us

If you have been diagnosed with triple-negative breast cancer or need further evaluation for a breast concern, we encourage you to reach out to our team. Please contact Dr. Michele Ley at Tucson Breast Health Specialists to schedule a consultation and learn more about your treatment and surgical options. We are here to support you with expert, compassionate care at every step.

Board-Certified Surgeon

MICHELE LEY, MD, FACS

Dr. Ley, a breast surgical oncologist in Tucson since 2006, delivers compassionate and personalized care to create tailored treatment plans based on the latest research. Specializing in surgical care for breast cancer and high-risk patients, she employs minimally invasive techniques and practices oncoplastic surgery to optimize outcomes.

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“The level of care is excellent.”

I have no words to express my gratitude for Dr. Ley! I was diagnosed Feb. 2020 and Dr. Ley besides being the best in her field and doing an amazing job on my double mastectomy she was even able to save my nipples. She is also a remarkable human being, patient, kind very clear in explaining everything and making you feel heard and safe in her hands. I 100% recommend her and her very helpful, kind and amazing team! If you have recently been diagnosed this is the team you want to have your back!

Dr. Ley is an excellence breast oncology surgeon, with incredible knowledge and genuine compassion. From the initial consultation to post-operative care, Dr. Ley’s meticulous approach and comprehensive understanding of breast oncology instilled confidence and eased my anxieties. The dedication to her patient’s well-being extends far beyond medical procedures; she fosters a supportive environment where empathy and personalized care is a priority.What sets Dr. Ley apart is her ability to treat not just the disease but the individual, providing unwavering support and guidance throughout the journey. Her warmth, coupled with a skilled surgical hand, empower patients with hope and resilience. Dr. Ley’s practice, marked by professionalism and kindness from every member of her team, ensures that patients receive not only top-notch medical care but also a nurturing environment conducive to healing. Dr. Ley is a beacon of hope and excellence in battling breast cancer.

Dr. Ley helped me through the first round of BC in 2017 with kindness, compassion and expertise! I had absolutely no reservations when trusting her for a 2021 and now for the 3rd time I can’t imagine going through this without her. She is a lion when it comes to fighting for you, calls you personally even though she has to be the busiest Dr. and mother I know. She’s considerate of your needs, fears and concerns and never lets you go it alone. Can’t say enough good!

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